On the rocky path to sobriety after a life-changing accident, John Callahan discovers the healing power of art, willing his injured hands into drawing hilarious, often controversial cartoons, which bring him a new lease on life.
Once called "Father Frank" for his efforts to rescue lives, Frank Pierce sees the ghosts of those he failed to save around every turn. He has tried everything he can to get fired, calling in sick, delaying taking calls where he might have to face one more victim he couldn't help, yet cannot quit the job on his own.
In the present, artist Tom Warshaw recalls his traumatic coming of age. As a 13-year-old growing up in New York City in 1973, Tom hangs out with Pappass, a mentally disabled man. With Tom's mother battling depression after the death of her husband, the young boy is left to his own devices. When Tom develops a crush on schoolmate Melissa, Pappass feels abandoned and begins behaving erratically.
Scott has been a case of arrested development ever since his firefighter father died when he was seven. He's now reached his mid-20s having achieved little, chasing a dream of becoming a tattoo artist that seems far out of reach. As his ambitious younger sister heads off to college, Scott is still living with his exhausted ER nurse mother and spends his days smoking weed, hanging with the guys — Oscar, Igor and Richie — and secretly hooking up with his childhood friend Kelsey. But when his mother starts dating a loudmouth firefighter named Ray, it sets off a chain of events that will force Scott to grapple with his grief and take his first tentative steps toward moving forward in life.
An agoraphobic woman living alone in New York begins spying on her new neighbors only to witness a disturbing act of violence.
Driving cross-country, Ray and his wife and daughter stop at a highway rest area where his daughter falls and breaks her arm. After a frantic rush to the hospital and a clash with the check-in nurse, Ray is finally able to get her to a doctor. While the wife and daughter go downstairs for an MRI, Ray, exhausted, passes out in a chair in the lobby. Upon waking up, they have no record or knowledge of Ray's family ever being checked in.
Al Fountain, a middle-aged electrical engineer, is on the verge of a mid-life crisis, when he decides to take his time coming home from a business trip, rents a car, and heads out looking for a lake he remembers from his childhood. But his wandering takes him into the life of Kid, a free-spirited young man who helps Al escape from the routine of everyday life and find freedom to enjoy himself.
Writer Harry Block draws inspiration from people he knows, and from events that happened to him, sometimes causing these people to become alienated from him as a result.
When the woman of his dreams is snatched by a strange ambulance, a young man risks it all to find her and tracks down a trafficking ring.
In a life full of triumph and failure, "National Lampoon" co-founder Doug Kenney built a comedy empire, molding pop culture in the 1970s.
After being double-crossed and left for dead, a mysterious man named Walker single-mindedly tries to retrieve the rather inconsequential sum of money that was stolen from him.
Intent on seeing the Cahulawassee River before it's turned into one huge lake, outdoor fanatic Lewis Medlock takes his friends on a river-rafting trip they'll never forget into the dangerous American back-country.
Tired of the noise and madness of New York and the crushing conventions of late Eisenhower-era America, itinerant journalist Paul Kemp travels to the pristine island of Puerto Rico to write for a local San Juan newspaper run by the downtrodden editor Lotterman. Adopting the rum-soaked lifestyle of the late ‘50s version of Hemingway’s 'The Lost Generation', Paul soon becomes entangled with a very attractive American woman and her fiancée, a businessman involved in shady property development deals. It is within this world that Kemp ultimately discovers his true voice as a writer and integrity as a man.
A car crash victim suddenly finds himself turned on by car accidents and becomes involved with an underground sub-culture of like-minded souls.
Writer Paul Benjamin is nearly hit by a bus when he leaves Auggie Wren's smoke shop. Stranger Rashid Cole saves his life, and soon middle-aged Paul tells homeless Rashid that he wouldn't mind a short-term housemate. Still grieving over his wife's murder, Paul is moved by both Rashid's quest to reconnect with his father and Auggie's discovery that a woman who might be his daughter is about to give birth.
Bailey and Darla embark upon a misguided and mutually deceitful form of therapy, one in which they must drive across the country, re-enacting Darla's colorful history as a sex addict. As their true motivations for the road trip come to light, the unlikely pair force one another to confront their issues, discovering that there might actually be more to love than just sex.
"Boxcar" Bertha Thompson, a transient woman in Arkansas during the violence-filled Depression of the early '30s, meets up with rabble-rousing union man "Big" Bill Shelly and the two team up to fight the corrupt railroad establishment.
Portland, Oregon, 1971. Bob Hughes is the charismatic leader of a peculiar quartet, formed by his wife, Dianne, and another couple, Rick and Nadine, who skillfully steal from drugstores and hospital medicine cabinets in order to appease their insatiable need for drugs. But neither fun nor luck last forever.
Aaron Falk returns to his drought-stricken hometown to attend a tragic funeral. But his return opens a decades-old wound - the unsolved death of a teenage girl.
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